PF-Atlas › Clinical Trials › NCT01852448
Genetics of Insulin and Incretins in Cystic Fibrosis
Blood or Saliva Sample Collection · Not specified
Registry ID
NCT01852448
Phase
Not specified
Status
Recruiting
Drug / intervention
Blood or Saliva Sample Collection
Sponsor
Children's Hospital of Philadelphia
Start
2013-05
Enrollment
550
Locations
2
About this trial
Cystic fibrosis related diabetes (CFRD) is associated with worse CF-relevant outcomes. The mechanisms underlying CFRD development are not fully understood, but recent evidence suggests Type 2 Diabetes Mellitus (T2DM) mechanisms may be involved and may involve incretins (gut secreted hormones that augment insulin secretion in response to a nutrient load). This study will examine the prevalence of Genome wide association study (GWAS)-implicated T2DM alleles (including TCF7L2) across the spectrum of glucose abnormalities in CF and will use this information to compare incretin and insulin secretion in non-diabetic children and adults with high risk and low risk alleles.
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Medical disclaimer. This page summarizes public trial data for NCT01852448 for information only. It is not medical advice, an endorsement, or an offer to enroll. Confirm details on ClinicalTrials.gov and with a qualified physician.