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YAP

Idiopathic Pulmonary Fibrosis · Blocks mechanosensing amplification loop — breaks stiffness-to-fibrosis cycle

Mechanism
Blocks mechanosensing amplification loop — breaks stiffness-to-fibrosis cycle
Development stage
Preclinical
Evidence level
Level 3 (Preclinical)
Developer
Multiple

Overview

Reverses established fibrosis in mice. YAP/TAZ activation by matrix stiffness is self-amplifying. Verteporfin is FDA-approved for other uses.

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Treatment profileBlocks mechanosensing amplification loop — breaks stiffness-to-fibrosis cycleAll trialsResearch
Medical disclaimer. This page summarizes research about YAP for information only. It is not medical advice. Verify approval status and evidence with the FDA and a pulmonologist.