OSK Partial Reprogramming of AEC2s
Idiopathic Pulmonary Fibrosis · Inhaled LNP-mRNA OSK resets epigenetic age of AEC2s — treats root cause
Mechanism
Inhaled LNP-mRNA OSK resets epigenetic age of AEC2s — treats root cause
Development stage
Preclinical
Evidence level
Level 3 (Preclinical)
Developer
Altos Labs / Shift Bio
Overview
AEC2 Horvath clock 10-15 years advanced in IPF. OSK reversal in optic nerve (Nature 2023). 2025 review: organ-specific dedifferentiation and epigenetic remodeling demonstrated in vivo. OSKM+TERT combination shows enhanced anti-aging effects. No AEC2-specific data yet but pathway proven.
Explore related
Medical disclaimer. This page summarizes research about OSK Partial Reprogramming of AEC2s for information only. It is not medical advice. Verify approval status and evidence with the FDA and a pulmonologist.