Lipofibroblast Niche Restoration
Idiopathic Pulmonary Fibrosis · PPAR-y agonist + FGF10 restores AEC2 metabolic support niche
Mechanism
PPAR-y agonist + FGF10 restores AEC2 metabolic support niche
Development stage
Preclinical
Evidence level
Level 3 (Preclinical)
Developer
Multiple
Overview
Lipofibroblasts replaced by myofibroblasts in IPF. PPAR-y agonists (pioglitazone) reverse this. FGF10 rebuilds MANC niche.
Explore related
Medical disclaimer. This page summarizes research about Lipofibroblast Niche Restoration for information only. It is not medical advice. Verify approval status and evidence with the FDA and a pulmonologist.